Getting Between Stops
Spain's high-speed trains do the heavy lifting. Madrid to Seville takes about two and a half hours from Atocha, with three companies competing on the route, so fares booked a few weeks out can be very low. Seville to Granada is slower, roughly two and a half to three hours, with fewer departures, so book that leg as soon as your dates are set.
For the trip home, Granada's small airport has domestic flights to Madrid. Book them as part of your international ticket where you can. The alternative is the train back to Madrid, about three and a half hours, which only works for a late flight or with a final night near the airport. Málaga (AGP) is about 90 minutes from Granada and has more European connections.
In all three cities you will walk almost everywhere. Taxis are cheap and plentiful for the hills of the Albaicín and late dinners.
Where to Stay
In Madrid, stay in Barrio de las Letras or near the Prado so the museums and tapas streets are on your doorstep. The Mandarin Oriental Ritz sits beside the Prado in a grand 1910 building and is the obvious splurge. Ask for an interior room in smaller hotels, since street noise carries late.
In Seville, look for a converted mansion around a patio in Santa Cruz or El Arenal. Corral del Rey and Hotel Mercer Sevilla are small restored houses with roof terraces. Hotel Alfonso XIII is the grand 1929 landmark beside the Alcázar quarter. After May, a rooftop plunge pool is worth paying for.
In Granada, the Albaicín has small hotels in old carmens with Alhambra views, though the lanes are steep and cobbled. The Parador de Granada, inside the Alhambra grounds, books up far ahead. Hotel Alhambra Palace is a good-value alternative on the same hill.
When to Go
Spring is the classic window. From March through May the orange trees in Seville flower, the Alhambra gardens fill with roses and daytime temperatures sit in the comfortable 70s. Holy Week and Seville's April Fair are spectacular but crowded, with hotel prices to match, so book very early or avoid those weeks.
Late September to early November is the other sweet spot, with warm evenings for eating outdoors and thinner crowds. Madrid can feel crisp by November, while Seville stays mild.
Skip July and August if you can. Seville and Córdoba regularly pass 104°F, which turns sightseeing into an endurance test. Many Madrid locals leave town in August. Winter is quiet and cheap, with cool nights and the Sierra Nevada snowcapped behind Granada, which suits couples who care more about museums than terraces.
What It Costs
This route is good value by Western European standards. As a rough guide, comfortable boutique hotels in all three cities run about $200 to $400 a night for two, with the grand addresses higher. Expect roughly $650 and up at Hotel Alfonso XIII and $1,000 or more at the Mandarin Oriental Ritz, as approximate starting points that rise in spring.
Trains are cheap if booked early and can cost several times more on the day. Tapas dinners in Granada are famously cheap, since drinks often come with a free plate of food. Seville and Madrid are pricier but still reasonable.
Set aside money for a few booked experiences: Alhambra tickets, a small flamenco venue, a bathhouse session and one tasting-menu dinner in Madrid. These are the moments couples remember. They cost far less than an extra night in a palace hotel.
Tips for the Two of You
Adjust to Spanish hours instead of fighting them. Lunch around two and dinner after nine means restaurants are lively when you arrive. A midafternoon rest is part of the culture rather than lost time.
Pack shoes with real grip for the Albaicín's cobbles and the Alhambra's long walks. Cathedrals and churches expect covered shoulders for both of you, so carry a light layer. In Seville from May onward, plan sightseeing for the morning and late evening and stay inside or in a pool through the hottest hours.
Pickpockets work the busiest spots in Madrid, around Puerta del Sol and on crowded metro lines, so keep phones zipped away. Taxis late at night are safe and easy to hail in all three cities. Book the Alhambra only through the official site or a well-known agency, since resale tickets in the wrong name can be refused at the gate.
Make It Shorter or Longer
With eight or nine days, cut Madrid to two nights and Seville to three, keeping Granada at three for the Alhambra. Or skip Madrid entirely: fly into Madrid and ride straight to Seville, then come back through the capital for one final night before flying home.
With two weeks, the easy addition is the coast. Drive from Granada to Ronda for two nights on its cliff above the gorge, then finish with three nights in Marbella before flying home from Málaga. Another option is a night in Córdoba between Seville and Granada, so you see the Mezquita in the quiet early morning rather than on a day trip.
Couples who love wine could add Toledo as an overnight stop or start the trip with two nights in La Rioja, about three and a half hours from Madrid by train.